Dosimetric consequences of 3D versus 4D PET/CT for target delineation of lung stereotactic radiotherapy

S Siva; B Chesson; JW Callahan; N Hardcastle; L Crawford; P Antippa; G Wright; MP Macmanus; RJ Hicks; T Kron; DL Ball

Journal article

Dosimetric consequences of 3D versus 4D PET/CT for target delineation of lung stereotactic radiotherapy

S Siva, B Chesson, JW Callahan, N Hardcastle, L Crawford, P Antippa, G Wright, MP Macmanus, RJ Hicks, T Kron, DL Ball

Journal of Thoracic Oncology | ELSEVIER SCIENCE INC | Published : 2015

DOI: 10.1097/JTO.0000000000000555

Abstract

Introduction: Lung tumor delineation is frequently performed using 3D positron emission tomography (PET)/computed tomography (CT), particularly in the radiotherapy treatment planning position, by generating an internal target volume (ITV) from the slow acquisition PET. We investigate the dosimetric consequences of stereotactic ablative body radiotherapy (SABR) planning on 3D PET/CT in comparison with gated (4D) PET/CT. Methods: In a prospective clinical trial, patients with lung metastases were prescribed 26 Gy single-fraction SABR to the covering isodose. Contemporaneous 3D PET/CT and 4D PET/CT was performed in the same patient position. An ITV was generated from each data set, with the pla..

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University of Melbourne Researchers

Shankar Siva Author

Nicholas Hardcastle Author

Phillip Antippa Author

Gavin Wright Author

Related Projects (1)

INVESTIGATING RADIATION RESPONSE AFTER HIGH-DOSE RADIOTHERAPY IN PATIENTS WITH CANCERS OF THE LUNG

Radiotherapy is a potentially curative treatment for cancers of the lung. To improve outcomes, modern research efforts have focussed on radi..

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

Dr. Shankar Siva has received National Health and Medical Research Council scholarship funding for this research, APP1038399. All other authors declare no conflict of interest.